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Alpha-Phenylacetoacetonitrile (APAAN)

90.003,650.00

You can purchase Alpha-Phenylacetoacetonitrile (APAAN) from Crown Chemicals. This chemical is available in powdered form with a purity of 99.8%. The minimum order quantity is 10kg and 1kg costs €90.

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Description

What is Alpha-Phenylacetoacetonitrile (APAAN)?

Alpha-Phenylacetoacetonitrile is a chemical with CAS number 4468-48-8 that has been categorized as a list I substance according to the  Controlled Substances Act (CSA). It is found to be used in clandestine chemical labs for manufacturing a schedule II controlled drug in an illegal manner, named phenyl-2-propanone or P2P), methamphetamine, and amphetamine. Because of this reason, DEA has proposed it to be a controlled substance.

Any chemical mixture which has Alpha-Phenylacetoacetonitrile is subject to the regulation by CSA except in certain cases when it may be exempted.

What are the synonyms of Alpha Phenylacetoacetonitrile?

Alpha Phenylacetoacetonitrile is known by the following names also:

  • APAAN
  • 2-Phenylacetoacetonitrile
  • NSC 11777
  • NSC 25183
  • NSC 55206

What are the different available forms of Alpha Phenylacetoacetonitrile?

This chemical is available in powdered form having a yellow, brown or white colour or even in the crystalline forms having a pale straw yellow colour.

Where to buy Alpha Phenylacetoacetonitrile?

Our online store is the best place to purchase Alpha Phenylacetoacetonitrile. The chemical supplied by us has a high level of purity. Not only this, you will get it from us at a price that is much less than most of the other suppliers providing the same in the market. Another exciting reason to opt for our online store is that we ship it through our trusted courier partners through discrete and secured global delivery to our customers staying in different countries around the globe.

What are the different properties of Alpha Phenylacetoacetonitrile?

The specific properties of this chemical are enumerated below:

<<<<<melting point, Boiling point, Density, CAS number, purity, Molecular weight etc) Use a table for this section.>>>

What are the uses of Alpha Phenylacetoacetonitrile?

There are no legal uses of Alpha Phenylacetoacetonitrile except that it is used for research and development works as well as analytical purposes in the laboratories.

Some of the popular vendors of this chemical:

Here is the list of some vendors of Alpha Phenylacetoacetonitrile:

  • Activate Scientific
  • Aurum Pharmatech LLC
  • MolPort
  • Heterocyclics Research Chemicals & Building blocks
  • Wolves R&D chemical
  • Alfa Chemistry
  • AK Scientific, Inc. (AKSCI)
  • Oakwood Products
  • Hangzhou APIChem Technology
  • Vitas-M Laboratory
  • LabNetwork, a WuXi AppTec Company
  • Chemieliva Pharmaceutical Co., Ltd

What is the process of synthesis or preparation of Alpha Phenylacetoacetonitrile?

60 gm of clean sodium is taken having 2.6-gram atoms is taken along with 700cc of absolute alcohol. Using this, a sodium ethoxide solution is made in a 2-1 round-bottomed flask that has a reflux condenser fitted to it. A mixture of 234 g or 2 moles of pure benzyl cyanide and 264 g or 3 moles of dry ethyl acetate is added to this hot solution, after which it is shaken properly. A calcium chloride tube is used to close the condenser. The solution is heated for two hours using a steam bath after which it is left overnight.  You can find that lumps have been formed in the mixture the next morning. So, a wooden rod is used for stirring the mixture, so that the lumps will break. After this, it is cooled to a temperature of −10° using a freezing mixture. Then this temperature is maintained for 2 hours. A  6-in. Büchner funnels are used to collect the sodium salt which is washed using 250-cc. portions of ether 4 times in the funnel. You will find a colorless filter cake that corresponds to 250–275 g. of dry sodium salt, or 69–76 percent of the calculated amount. Place the combined filtrates in the freezing mixture.

Dissolve the sodium salt which is still wet with ether, in 1.3l of distilled water at room temperature and then cools the solution to  0°. By maintaining the temperature below 10°, precipitate nitrile by adding 90cc glacial acetic acid slowly and shaking vigorously. With suction filtration, separate the precipitate and wash it 4 times in 250 cc water using a funnel. Now you will get a moist cake of α-Phenylacetoacetonitrile, with a weight of 300 g corresponding to 188-206 g. It is 59-64% dry with a melting point of 87–89° that fits most of the purposes.

In case you want to recrystallize the crude chemical, then dissolve the moist cake in 100cc of hot methyl alcohol. Filter the solution and cool it by stirring it to get a temperature of  −10°. Filter the crystals using suction filtration and wash it one time on the filter with 40cc of methyl alcohol cooled to −10°. In dry condition, the product weighs  173–191 g. (54–60 percent) and has a  melting point of  88.5–89.5°. Place the filtrates and washings from the separation of sodium salt in a 5-1. flask. You can dilute it with ice cold water till the flask is full. Remove the lower layer completely by siphoning. A major part of the ether can be removed through the process of decantation and separate the remaining using a separatory funnel.

In the same manner, extract the aqueous layer two times with 500 cc portions of ether after which you can discard the ether extracts.

You can remove the remaining ether in the aqueous layer at reduced pressure by using a suction pump to suck air through the solution for an hour. Precipitate the α-Phenylacetoacetonitrile by adding 60cc of glacial acetic acid.

In case oil is thrown out, place the flask in the ice bath till the precipitate is crystalline. Use suction filtration for separating the crystals and washing it four times in a funnel with 50cc of water. In dry condition, the tan-coloured substance has a weight of 50-55g which has a melting point of  83–86°. Then dissolve it in the methyl alcohol mother liquors from the crystallization of the first lot. The resulting solution is boiled with a small amount of Norite. It is filtered and cooled to −10°. Collect the crystals which are formed using a filter and wash them with 10cc of cold methyl alcohol, after which it has to be dired. Then a 43-48 gram substance is obtained having a pale straw colour with a melting point of 87–89°. It is recrystallized from 25cc pure methyl alcohol, which is washed using 10cc  of cold methyl alcohol. A 37–41 g substance is obtained with a melting point of  88.5–89.5°. This yields a total material of this much purity of 210–232 g which is 66–73% of the theoretical amount.

What are the different properties of Alpha Phenylacetoacetonitrile?

The specific properties of this chemical are enumerated below:

Property Value
Molecular Weight 159.188 g/mol
Exact Mass 159.068 g/mol
CAS number 4468-48-8
Purity 99.8%

At what price is  Alpha Phenylacetoacetonitrile available?

The price at which this chemical is available varies from one supplier to a supplier. The exact price depends on the discount offered by an online store and the amount of chemical you are purchasing. We can assure you that at our store you can find it at the best price in the market. Besides this, we guarantee the product quality and also ensure a fast delivery at your doorsteps.

What is the legal status of Alpha Phenylacetoacetonitrile?

Since Alpha Phenylacetoacetonitrile is a list I chemical, all the transactions which involve it are regulated  irrespective of the size,

In case of the mixtures containing this chemical that do not qualify for the automatic exemption, the manufacturers need to submit an application to exempt them because all the chemical mixtures containing it at any concentration come under the regulatory requirements.

What are the warnings regarding this chemical that you need to follow?

There are certain precautions which you need to follow to ensure safety while handling this chemical. The warnings and the precautions are enlisted below:

  1. This chemical has acute toxicity if consumed orally. So avoid consuming it at any cost.
  2. It is toxic if it comes in contact with your skin, so, in order to avoid harm, you need to handle them with utmost care, by using gloves so that your skin remains protected.
  3. You will have to face irritation in the skin and even it may get corroded, so make sure to avoid contact directly.
  4. The chemical is known to cause serious irritation in the eyes leading to damage so wear good glasses that cover the eyes completely and thus ensuring protection from accidental contact with eyes.
  5. It proved to be highly toxic if inhaled. So the face must be masked, to make sure that there is no accidental inhalation of the chemical when you are handling it for research, development or analytical purposes.
  6. The drug is potent enough to cause respiratory irritation. Iy can cause target organ toxicity even if it is exposed for a single time. You can experience severe irritation, especially in your respiratory tract.
Additional information
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1Kg APAAN Powder, 10Kg APAAN Powder, 25Kg APAAN Powder, 50Kg APAAN Powder

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